Methodology

This list is based on analysis of Cambridge IGCSE Biology 0610 past papers (2019–2024), examiner reports, mark schemes and topical question banks. Topics are ranked by frequency of appearance and mark allocation across Papers 1–6.

Top 10 most frequently tested topics

1. Enzymes

Evidence: Consistently appears across papers; high question count in topical banks (e.g. 47+ questions). Examiner reports repeatedly note enzyme-related errors (pH, temperature, specificity).

Covers: enzyme action, active site, lock-and-key; effect of temperature and pH; denaturation; enzyme investigations.

2. Movement in and out of cells

Evidence: Diffusion, osmosis and active transport appear in almost every exam series. Common confusion (examiner reports) on water potential and concentration gradient.

Covers: diffusion, osmosis, active transport; experiments; water potential.

3. Organisation of the organism / Cell structure

Evidence: Cell structure, magnification and organelle function feature regularly. Topical banks show 46+ questions. Frequent errors on mitochondria vs ribosomes.

Covers: cell structure, magnification calculations, organelles, tissues, organs.

4. Human nutrition

Evidence: Digestion, balanced diet, enzymes in digestion appear often. Linked to practical work (Paper 6) and theory.

Covers: diet, digestion, absorption; mechanical and chemical digestion; role of enzymes.

5. Respiration

Evidence: Aerobic and anaerobic respiration; gas exchange link. Core topic in every series.

Covers: aerobic vs anaerobic; word equation; practical applications.

6. Transport in animals

Evidence: Blood, heart, circulation appear regularly. Examiner reports note confusion on blood components and vessel function.

Covers: circulatory system, heart structure, blood vessels, blood components.

7. Inheritance and variation

Evidence: Genetics, inheritance patterns and classification appear in extended content. Significant mark allocation.

Covers: genes, alleles, inheritance; genetic diagrams; variation.

8. Plant nutrition (Photosynthesis)

Evidence: Photosynthesis and plant structure feature in most papers. Linked to practical investigations.

Covers: photosynthesis equation; leaf structure; factors affecting rate.

9. Coordination and response

Evidence: Nervous system, hormones and reflex arcs appear across papers. Examiner reports note confusion on reflex pathway.

Covers: nervous system, reflex arc, hormones, homeostasis.

10. Characteristics and classification of living organisms

Evidence: MRS GREN, classification, kingdoms. Foundation topic; appears in Core papers and MC.

Covers: characteristics of life; classification; kingdoms; keys.

Revision priority

Focus on Enzymes, Movement in and out of cells and Cell structure first—they appear most often and carry significant marks. Combine with common mistakes to avoid examiner-reported errors.

How Tutopiya helps

Tutopiya supports Cambridge IGCSE Biology with topic-focused revision. Explore IGCSE resources or book a free trial.

---

Sources: Cambridge past papers 2019–2024, examiner reports, SaveMyExams topical analysis, syllabus 2023–2025.