Infection and ResponseAQA GCSE Biology (8461)

Monoclonal Antibodies

Work through the notes, try the practice questions, then take the quiz. The report tells you exactly what to revise next. (2026)

Practice progress

5 MCQs

0 of 5 attempted

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Remaining

1
What is a monoclonal antibody?
Answer & explanation
Correct: option B
Monoclonal means 'from one clone' — all the antibody molecules are identical and bind one specific antigen.
2
Why are mouse lymphocytes fused with tumour cells?
Answer & explanation
Correct: option B
Lymphocytes alone don't divide indefinitely. Tumour cells contribute that ability so the hybridoma can be cultured forever.
3
What is a hybridoma?
Answer & explanation
Correct: option C
Hybridoma = lymphocyte + myeloma cell fused. It makes antibody AND divides indefinitely.
4
From which organ of the mouse are lymphocytes harvested?
Answer & explanation
Correct: option C
AQA wording: lymphocytes are removed from the spleen, which is rich in B-cells responding to the injected antigen.
5
Who developed the original hybridoma technique that produces monoclonal antibodies?
Answer & explanation
Correct: option C
Milstein and Köhler at the MRC Cambridge developed the technique in 1975 and shared the 1984 Nobel Prize.

Infection and ResponseAQA GCSE Biology (8461)

Work through the notes, try the practice questions, then take the quiz. The report tells you exactly what to revise next. (2026)

5 MCQs

0 of 5 attempted

Correct

Incorrect

Remaining

1
What is a monoclonal antibody?
Answer & explanation
Correct: option B
Monoclonal means 'from one clone' — all the antibody molecules are identical and bind one specific antigen.
2
Why are mouse lymphocytes fused with tumour cells?
Answer & explanation
Correct: option B
Lymphocytes alone don't divide indefinitely. Tumour cells contribute that ability so the hybridoma can be cultured forever.
3
What is a hybridoma?
Answer & explanation
Correct: option C
Hybridoma = lymphocyte + myeloma cell fused. It makes antibody AND divides indefinitely.
4
From which organ of the mouse are lymphocytes harvested?
Answer & explanation
Correct: option C
AQA wording: lymphocytes are removed from the spleen, which is rich in B-cells responding to the injected antigen.
5
Who developed the original hybridoma technique that produces monoclonal antibodies?
Answer & explanation
Correct: option C
Milstein and Köhler at the MRC Cambridge developed the technique in 1975 and shared the 1984 Nobel Prize.