Asymmetric information exists when one party in a transaction has more or better information than the other. It can cause markets to fail by leading to inefficient or even missing markets.
How it causes market failure. Two key problems arise. Adverse selection occurs before a transaction, when one party hides their 'type': in insurance, high-risk individuals know they are high-risk and are most likely to buy cover, raising premiums and driving out low-risk buyers, so the market may shrink or collapse. In the famous 'market for lemons', used-car sellers know quality but buyers don't, so buyers offer only an average price, good cars are withdrawn, and the market unravels. Moral hazard occurs after a transaction: once protected or insured, a party takes more risk (e.g. an insured driver is less careful; a bailed-out bank takes excessive risks), because it does not bear the full consequences. Both lead to a misallocation of resources and reduced welfare, so the market fails to achieve an efficient outcome.
Qualifications — markets and others can respond. Markets often develop their own solutions that limit the failure: signalling (e.g. warranties, qualifications, brand reputation) and screening (e.g. insurers using risk assessments, no-claims bonuses) reduce the information gap. Repeated transactions and reputation discipline sellers. Government intervention (regulation, mandatory disclosure, licensing, compulsory insurance) can also correct it. So the failure is not always severe or permanent. Moreover, asymmetric information is only one source of market failure among several (externalities, public goods, monopoly), and its importance varies by market — it is severe in insurance, healthcare and second-hand goods, but minor for simple, repeated everyday purchases.
Judgement. Asymmetric information can cause significant market failure, especially in insurance, finance, healthcare and second-hand goods, where adverse selection and moral hazard are serious. However, the extent of the failure is limited by market-based responses (signalling, screening, reputation) and by government intervention, and it is negligible in many simple markets. The most defensible conclusion is that asymmetric information is a genuine and important cause of market failure in specific markets, but its overall extent depends on the market and on the corrective mechanisms available — so it does not cause widespread, uncorrectable failure across the economy.